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Even in ancient instances people are unaware of your existence of living organisms invisible for the eye, causing disease. Therefore, the ancient Greek scientist and physician Hippocrates expressed this assumption in one of his performs. But come to grips with their study of mankind has been able only just after the Dutch optician van Leeuwenhoek in the XVI century developed the very first microscope and saw firsthand the bacteria in essay stone com a drop of water. Nonetheless, numerous inside the class scientist denied the existence of pathogens inside some centuries just after the invention of Leeuwenhoek.